a bid submitted by a bidder as an alternative bid or offer along with the main bid alternative bids are frequently in response to a requirement specified in the bid documents sometimes bidders submit alternative bids voluntarily
... preventing it from interacting with ascorbate Table Steady-state kinetic parameters of APXs To investigate the role of Trp35 inthe cross-link and the inactivation of APX by H2O2, we created a mutant ... tsAPX and tsAPXW35F appeared as single bands when separated by SDS ⁄ PAGE (data not shown) O2-free APX solution was prepared by passing APX in 10 mm potassium phosphate, pH 7.0, mm EDTA, mm ascorbate, ... contaminating apoprotein (data not shown) These results strongly support the idea that the formation of the cross-link is at least part of the reason for the rapid inactivation of tsAPX In these...
... On the other hand, to cool air in summer, mainly in hot and dry climates, the process of evaporative or adiabatic cooling appears asanalternative There are many systems that can operate as ... stream and transfer it tothe secondary air inthe evaporative cooling process They can be made either of metal or plastic and must easily conduct heat, maintain the two streams separated and ... Legionnaire’s disease The bacteriological contamination, mainly by legionnaire’s bacteria, has become themain disadvantage of the evaporative cooling systems Therefore, this implies that in many cases...
... consultants to and SK is an employee of Astellas SK is a stock holder in Astellas Pharma US, Inc, the manufacturer of micafungin AFS and MDZ have received research and consulting funding, and SK ... combined witha large decrement inthe remaining quality of life, the cost remains $50,722 per QALY Inthe worst-case analysis, with all of the inputs skewed maximally against MIC, the incremental ... scenario, with all inputs biased against the empiric MIC vs FLU strategy Input Candidemia as % BSI CK/CG as % candidemia Candidemia attributable mortality Candidemia mortality reduction if treated...
... cells withthe mTOR inhibitor, rapamycin, increased BIM expression and overcame RAS-dependent survival signals to promote cell death, arguing that mTOR was an important survival signal that acted, ... imatinib therapy have point mutations inthe BCR–ABL kinase domain, including the T315I gatekeeper mutation that impairs imatinib binding [58,59] Accordingly, new therapies are being tested and ... signal transducer and activator of transcription (JAK-STAT) pathway, to promote proliferation, survival and transformation [56,57] The importance of the BCR–ABL tyrosine kinase inthe survival...
... copper amalgam, performed manual mixing ina mortar, and used a Dentomat Taking the answers from the interview on these questions asthe true answer and comparing this tothe similar answers from the ... nurses and the dentist in regard tothe questions asto whether the amalgam was soft or firm As it was the dental nurses inthe clinics who filled the Dentomat and who prepared the amalgam for use ... of the study and the drafting of the manuscript KS has in addition performed the analyses Both authors have read and approved the final manuscript Competing interests The authors declare that they...
... (range - 16) at t1 and M = 9.16 years (range - 16) at t2 The Tanzanian and German board of the organization managing the orphanage gave their consent and ethical approval Materials The interview ... periods of assessment, interviewers and translators stayed inthe orphanage and shared the meals withthe children and played with them in their free time Analyses All variables except one met the preconditions ... Although many orphanages exist and care for OVC, a detailed evaluation of education and care in orphanages lacks in most cases However, some studies have examined aspects of how orphanages could...
... create, alter and drop database entities and insert data into a database Reverse engineering database schemas from existing databases is also supported The format is compatible with both PEAR::MDB ... variable instead of the database, which is a lot quicker A call to setField() can update the member variable, not the database— again, far quicker, and safe When all the changes are made, a call ... define(DATABASE_HOSTNAME, “localhost”); define(DATABASE_BASENAME, “phpa”); $GLOBALS[“db”] = pg_Connect(“user=’” DATABASE_USERNAME “‘ password=’” DATABASE_PASSWORD “‘ dbname=’” DATABASE_BASENAME...
... and then gradually increased up to 10 h, when maximal incorporation was attained This was followed bya decrease Under hypoxia, in contrast, incorporation decreased toa background level during ... that after medium exchange and further normoxic gassing first mitotic cells appear after about 13 h, their number increases within the next h and decreases again at longer incubation A similar increase ... DNA was detectable and the amount of PCNA not extractable by Triton buffer was high inthe same cells These results clearly show that the PCNA staining is colocated withthe BrdU staining and...
... greater Asa result, an increase in capital leads toa decrease inthe demand for future capital, K’ An increase inthe marginal cost of loans leads the bank to forecast a higher marginal cost inthe ... deposits and the provision for loan losses would lead toan increase inthe loan rate, since the marginal cost of loans would increase The marginal cost also increases withan increase in RAROC This ... that an increase inthe loan rate would reduce the demand for loans, and hence loans issued bythe bank On the other hand, an increase in economic activity is expected to increase the demand for...
... Factor Competing interests The University of Michigan and RJB have submitteda patent regarding the use of Alemtuzumab asan anti-angiogenic agent in ovarian cancer This was submitted after the ... and 7-Amino Actinomycin D (7-AAD BD Pharmingen) and analyzed by FACS Once again to assess cellular viability an aliquot of cells which receive no treatment were maintained at 37C inthe ascites ... 6B and 6C) Finally, we used an orthotopic intraperitoneal model of ovarian cancer to assess the impact of therapy on animal survival In this model animal reproducibly develop tumor associated ascites...
... the noise variances at the various CPEs arethe same The analysis does not provide any justification for the assumption that the estimation error variances are equal within one line i as (53) only ... (or decreasing noise variance) It can also be seen that the gain is indeed higher than for reasonable cases: it does not seem reasonable to allow the interference, which is due to changes inthe ... limited amount of information about the signal received at the CPEs Now thanks tothe coordination at the CO, all symbols transmitted to all different lines are known, and that additional information...
... Publishing House Li, Tana 1996 “Peasants on the Move: RuralUrban Migration inthe Hanoi Region.” 30 Occasional Paper, No 91 Singapore: Institute of Southeast Asian Studies Salant, P., and D .A Dillman ... agricultural land area of the households and their livelihood strategy, agricultural land area per capita as well as agricultural land area per laborer of the households have a relationship with their ... of the commune The data gained from the survey was utilized to describe the urban linkages of the local households withthe Hanoi urban area In addition, the data was also used to examine relations...
... ΨΠ, and the ΨΠ value varie with both investigator and species, summarize the effects of the variations inthe ln RWC/(–ln (–ΨΠ)) relationship, and are calculated by many authors asan indicator ... and A = [21] When the increase in solute concentration was more than that resulting from a decrease in water content (the passive component), then osmoregulation was active and A was less than ... resistance for annual and woody plants [7, 22, 26, 32, 33] Reduced osmotic potential allows the plant to maintain turgor, and therefore turgor-dependent processes such as cell expansion and stomatal...
... transport rate, and respiration rate) are linearly related to leaf nitrogen content on an area basis Na [41] Na is correlated tothe actual time-integrated leaf irradiance as [40]: Na ... walnut are given in [41] Carbon losses are split into growth respiration R g (associated withthe synthesis of new biomass) and maintenance respiration Rm (associated withthe maintenance and turn-over ... is the amount of carbon that has actually been incorporated inthe organ at t – according to assimilate availability This formulation relies on the observation that the activity of the enzymatic...
... model, with treatment and country as factors and baseline score asa covariate Changes from baseline are presented as leastsquares (LS) means and standard errors (SEs) Change from baseline in PANSS ... PANSS total score was further evaluated for all subjects using a mixed model with time, country, treatment, and treatment -by- time interaction as factors and baseline value asa covariate An unstructured ... Helsinki and that are consistent with good clinical practice and applicable regulatory requirements The original study protocol was reviewed and approved byan independent ethics committee oran institutional...
... presence inthe tongue may indicate an origin ina minor salivary gland Adenocarcinomas of the tongue are rare and represent the minority (20 to 25%) of the salivary gland tumors affecting the tongue ... Auris Nasus Larynx 2004, 31:85-88 Tanaka T, Watanabe T, Kazama Y, Tanaka J, Kanazawa T, Kazama S, Nagawa H: Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: ... to activate Ras and its signaling pathways [30] Aberrations leading to increased activation of the PI3K/AKT pathway are common in human cancers and are reviewed in [31] Inactivating mutations and...
... statistical analysis Analysis of Fibrotic Area The percentage of fibrotic area inthe infarct and periinfarct zone was calculated in each heart using the image analysis software (Scion Image Beta 4.02 ... transplantation compared to those of BM-MNC transplantation and the anti-inflammatory role of transplanted cells after implanted into a rat chronic myocardial infarction Survived donor cells in ... Komeda M: Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality...
... renal clearance, increases bleeding diathesis and it is also antigenic It is almost the same size molecule as both protamine and aprotinin Both of these agents are known for their antigenicity As ... systemically anticoagulate a patient during CPB, instead of heparin has important implications It renders the standard ACT testing, inadequate Moreover, lepirudin cannot be reversed, aswiththe heparin-protamine ... unavailability in standard hospital laboratories Furthermore, the unavailability of a reversing agent greatly increases the potential for peri-operative bleeding These difficulties can be addressed...
... the needle directed cranially and the tracheal cannula inserted witha pull-through technique alongthe orotracheal route The cannula is then rotated downward using a plastic obturator Themain ... them are minor With proper patient selection, operator experience and attention to detail, complication rates can be reduced that may have an influence on late complications An important advantage ... percutaneous dilatational tracheostomy Figures on late complications after decannulation, including tracheal stenosis, hoarseness and tracheomalacia, are difficult to analyze since the criteria applied...
... failure to clear the organism [6,7] Inthe initial phase of infection, Listeria binds to splenic macrophages and is internalized; Listeria produces products that activate nuclear factor-kappa ... Zeng S, Yan SF, Ramasamy R, Emond J, Clynes R, Schmidt AM: Receptor for advanced glycation end products (RAGE) ina dash tothe rescue: inflammatory signals gone awry inthe primal responseto stress ... growth and metastases Nature 2000, 405:354-360 13 Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, et al.: HMG-1 asa late mediator of...